Welcome to SEPS, your go-to experts in Sterile Compounding Pharmacy Compliance! We understand how important it is to keep pharmacies clean and safe for both the pharmacy staff and the patients they serve. In this blog post, we will discuss an essential aspect of pharmacy safety called USP 800 Surface Wipe Sampling and why it matters.

What is USP 800?

USP stands for United States Pharmacopeia, an organization that sets standards for the quality and safety of medications. USP 800 specifically focuses on handling hazardous drugs in healthcare settings, including pharmacies. These drugs, although necessary for patient care, can pose risks if not handled properly.

Why is Surface Wipe Sampling Important?

Surface Wipe Sampling is a method that helps check the cleanliness of surfaces in a pharmacy. It involves using special wipes to collect samples from different areas such as countertops, equipment, and workspaces. Analyzing these samples can help detect any residue or contamination that might be present.

Performing Surface Wipe Sampling regularly ensures that workspaces are clean and free from hazardous drug residues. This helps protect the pharmacy staff from accidental exposure and prevents the risk of contamination that could potentially harm patients.

How Does Surface Wipe Sampling Work?

Surface Wipe Sampling is a straightforward process. Here’s a step-by-step explanation:

  1. Preparation: Before sampling, pharmacy staff wear appropriate personal protective equipment (PPE) to protect themselves. This usually includes gloves, gowns, and masks.
  2. Collecting Samples: Using special wipes provided by SEPS, staff gently swipe designated surfaces to pick up any residue. These wipes are designed to capture even the tiniest traces of hazardous drugs.
  3. Packaging: Once collected, staff carefully seal the samples in sterile containers and label them for identification.
  4. Analysis: The collected samples are sent to a laboratory where experts use advanced techniques to analyze them. This analysis helps determine if any hazardous drug residue is present on the surfaces.
  5. Reporting: Once the analysis is complete, SEPS provides a detailed report to the pharmacy, outlining the results and any necessary actions that need to be taken to maintain a safe environment.

Benefits of Surface Wipe Sampling:

  1. Staff Protection: Regular sampling ensures that pharmacy staff work in a clean and safe environment, reducing the risk of accidental exposure to hazardous drugs.
  2. Patient Safety: By maintaining clean surfaces, pharmacies minimize the chance of drug contamination, safeguarding patients’ health and well-being.
  3. Compliance: USP 800 Surface Wipe Sampling helps pharmacies meet regulatory requirements and demonstrate their commitment to providing quality care.


At SEPS, we prioritize the safety and compliance of sterile compounding pharmacies. Furthermore, USP 800 Surface Wipe Sampling plays a crucial role in maintaining a clean and safe environment for both pharmacy staff and patients. Regularly performing this sampling allows pharmacies to identify and address potential hazards, ensuring the highest standards of safety and quality in pharmaceutical compounding.

Remember, a clean pharmacy is a healthy pharmacy, and SEPS is here to support your compliance needs every step of the way. Stay safe and keep compounding with confidence!

Pharmacist making a capsule of medicine using a manual machine